Fertility Preservation in Childhood Cancer: Endocrine Activity in Prepubertal Human Testis Xenografts Exposed to a Pubertal Hormone Environment

Fertility Preservation in Childhood Cancer: Endocrine Activity in Prepubertal Human Testis Xenografts Exposed to a Pubertal Hormone Environment

Survivors of childhood cancer are at risk for long-term treatment-induced health sequelae, including gonadotoxicity and iatrogenic infertility. At present, for prepubertal boys there are no viable clinical options to preserve future reproductive potential. We investigated the effect of a pubertal in...

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Bibliographic Details
Main Authors: Marsida Hutka, Prashant Kadam, Dorien Van Saen, Natalie Z. M. Homer, Jaime Onofre, W. Hamish B. Wallace, Lee B. Smith, Jan-Bernd Stukenborg, Ellen Goossens, Rod T. Mitchell
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Cancers
Subjects:
prepubertal human testis
childhood cancer
gonadotoxicity
side effects
steroidogenesis
testosterone
Online Access:https://www.mdpi.com/2072-6694/12/10/2830

Internet

https://www.mdpi.com/2072-6694/12/10/2830

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