HIV-1 replication fitness of HLA-B*57/58:01 CTL escape variants is restored by the accumulation of compensatory mutations in gag.

HIV-1 replication fitness of HLA-B*57/58:01 CTL escape variants is restored by the accumulation of compensatory mutations in gag.

Expression of HLA-B*57 and the closely related HLA-B*58:01 are associated with prolonged survival after HIV-1 infection. However, large differences in disease course are observed among HLA-B*57/58:01 patients. Escape mutations in CTL epitopes restricted by these HLA alleles come at a fitness cost an...

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Bibliographic Details
Main Authors: Esther F Gijsbers, K Anton Feenstra, Ad C van Nuenen, Marjon Navis, Jaap Heringa, Hanneke Schuitemaker, Neeltje A Kootstra
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3855271?pdf=render

Internet

http://europepmc.org/articles/PMC3855271?pdf=render

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