Endoplasmic reticulum stress regulates the intestinal stem cell state through CtBP2

Endoplasmic reticulum stress regulates the intestinal stem cell state through CtBP2

Abstract Enforcing differentiation of cancer stem cells is considered as a potential strategy to sensitize colorectal cancer cells to irradiation and chemotherapy. Activation of the unfolded protein response, due to endoplasmic reticulum (ER) stress, causes rapid stem cell differentiation in normal...

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Bibliographic Details
Main Authors: Bartolomeus J. Meijer, Wouter L. Smit, Pim J. Koelink, Barbara F. Westendorp, Ruben J. de Boer, Jonathan H. M. van der Meer, Jacqueline L. M. Vermeulen, James C. Paton, Adrienne W. Paton, Jun Qin, Evelien Dekker, Vanesa Muncan, Gijs R. van den Brink, Jarom Heijmans
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-89326-w

Internet

https://doi.org/10.1038/s41598-021-89326-w

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