Analysis of Amyloid Precursor Protein function in Drosophila melanogaster

The Amyloid precursor protein (APP) has mainly been investigated in connection with its role in Alzheimer’s disease due to its cleavage resulting in the production of the Aβ peptides that accumulate in the plaques characteristic for this disease. However, APP is an evolutionary conserved protein tha...

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Bibliographic Details
Main Author: Doris Kretzschmar
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-07-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnmol.2016.00061/full