Anti-PD-1 Therapy Does Not Influence Hearing Ability in the Most Sensitive Frequency Range, but Mitigates Outer Hair Cell Loss in the Basal Cochlear Region

Anti-PD-1 Therapy Does Not Influence Hearing Ability in the Most Sensitive Frequency Range, but Mitigates Outer Hair Cell Loss in the Basal Cochlear Region

The administration of immune checkpoint inhibitors (ICIs) often leads to immune-related adverse events. However, their effect on auditory function is largely unexplored. Thorough preclinical studies have not been published yet, only sporadic cases and pharmacovigilance reports suggest their signific...

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Bibliographic Details
Main Authors: Judit Szepesy, Gabriella Miklós, János Farkas, Dániel Kucsera, Zoltán Giricz, Anita Gáborján, Gábor Polony, Ágnes Szirmai, László Tamás, László Köles, Zoltán V. Varga, Tibor Zelles
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
immune checkpoint inhibitor
anti-PD-1 antibody
hearing loss
immune-related adverse events (irAE), auditory brainstem response (ABR)
cochleogram
spiral ganglion neuron
Online Access:https://www.mdpi.com/1422-0067/21/18/6701

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https://www.mdpi.com/1422-0067/21/18/6701

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