Cardiac Extracellular Matrix Hydrogel Enriched with Polyethylene Glycol Presents Improved Gelation Time and Increased On-Target Site Retention of Extracellular Vesicles

Cardiac Extracellular Matrix Hydrogel Enriched with Polyethylene Glycol Presents Improved Gelation Time and Increased On-Target Site Retention of Extracellular Vesicles

Stem-cell-derived extracellular vesicles (EVs) have demonstrated multiple beneficial effects in preclinical models of cardiac diseases. However, poor retention at the target site may limit their therapeutic efficacy. Cardiac extracellular matrix hydrogels (cECMH) seem promising as drug-delivery mate...

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Bibliographic Details
Main Authors: Lidia Gómez-Cid, María Luisa López-Donaire, Diego Velasco, Víctor Marín, María Isabel González, Beatriz Salinas, Lorena Cussó, Ángel García, Susana Belén Bravo, María Eugenia Fernández-Santos, Carlos Elvira, Johanna Sierra, Ester Arroba, Rafael Bañares, Lilian Grigorian-Shamagian, Francisco Fernández-Avilés
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
extracellular vesicles
hydrogel
extracellular matrix
drug delivery
polyethylene glycol
cardiac regenerative therapy
Online Access:https://www.mdpi.com/1422-0067/22/17/9226

Internet

https://www.mdpi.com/1422-0067/22/17/9226

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