Discovery of a molecular glue promoting CDK12-DDB1 interaction to trigger cyclin K degradation

Discovery of a molecular glue promoting CDK12-DDB1 interaction to trigger cyclin K degradation

Molecular-glue degraders mediate interactions between target proteins and components of the ubiquitin-proteasome system to cause selective protein degradation. Here, we report a new molecular glue HQ461 discovered by high-throughput screening. Using loss-of-function and gain-of-function genetic scre...

Full description

Bibliographic Details
Main Authors: Lu Lv, Peihao Chen, Longzhi Cao, Yamei Li, Zhi Zeng, Yue Cui, Qingcui Wu, Jiaojiao Li, Jian-Hua Wang, Meng-Qiu Dong, Xiangbing Qi, Ting Han
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-08-01
Series:eLife
Subjects:
molecular glue
target identification
targeted protein degradation
CDK12/CCNK
Online Access:https://elifesciences.org/articles/59994

Internet

https://elifesciences.org/articles/59994

Similar Items