Genetic variants modulate gene expression statin response in human lymphoblastoid cell lines

Genetic variants modulate gene expression statin response in human lymphoblastoid cell lines

Abstract Background Statins are widely prescribed to lower plasma low-density lipoprotein cholesterol levels. Though statins reduce cardiovascular disease risk overall, statin efficacy varies, and some people experience adverse side effects while on statin treatment. Statins also have pleiotropic ef...

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Bibliographic Details
Main Authors: Elizabeth Theusch, Yii-Der I. Chen, Jerome I. Rotter, Ronald M. Krauss, Marisa W. Medina
Format: Article
Language:English
Published: BMC 2020-08-01
Series:BMC Genomics
Subjects:
Statin
Expression quantitative trait locus (eQTL)
Gene-environment interaction
RNA-sequencing
Lymphoblastoid cell line
Online Access:http://link.springer.com/article/10.1186/s12864-020-06966-4

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http://link.springer.com/article/10.1186/s12864-020-06966-4

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