Operant self-stimulation of dopamine neurons in the substantia nigra.

We examined the contribution of the nigrostriatal DA system to instrumental learning and behavior using optogenetics in awake, behaving mice. Using Cre-inducible channelrhodopsin-2 (ChR2) in mice expressing Cre recombinase driven by the tyrosine hydroxylase promoter (Th-Cre), we tested whether selec...

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Bibliographic Details
Main Authors: Mark A Rossi, Tatyana Sukharnikova, Volodya Y Hayrapetyan, Lucie Yang, Henry H Yin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3673941?pdf=render