Somatic mutagenesis with a Sleeping Beauty transposon system leads to solid tumor formation in zebrafish.

Somatic mutagenesis with a Sleeping Beauty transposon system leads to solid tumor formation in zebrafish.

Large-scale sequencing of human cancer genomes and mouse transposon-induced tumors has identified a vast number of genes mutated in different cancers. One of the outstanding challenges in this field is to determine which genes, when mutated, contribute to cellular transformation and tumor progressio...

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Bibliographic Details
Main Authors: Maura McGrail, Julia M Hatler, Xianyan Kuang, Hsin-Kai Liao, Kishore Nannapaneni, Kristin E Noack Watt, Juli D Uhl, David A Largaespada, Erik Vollbrecht, Todd E Scheetz, Adam J Dupuy, Jesse M Hostetter, Jeffrey J Essner
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-04-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3080878?pdf=render

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http://europepmc.org/articles/PMC3080878?pdf=render

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