Protective effects of heat shock protein 27 in a model of ALS occur in the early stages of disease progression

Protective effects of heat shock protein 27 in a model of ALS occur in the early stages of disease progression

Amyotrophic lateral sclerosis (ALS) is a fatal neuromuscular disorder, characterised by progressive motor neuron degeneration and muscle paralysis. Heat shock proteins (HSPs) have significant cytoprotective properties in several models of neurodegeneration. To investigate the therapeutic potential o...

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Bibliographic Details
Main Authors: Paul S. Sharp, Mohammed T. Akbar, Sonia Bouri, Atsushi Senda, Kieran Joshi, Han-Jou Chen, David S. Latchman, Dominic J. Wells, Jacqueline de Belleroche
Format: Article
Language:English
Published: Elsevier 2008-04-01
Series:Neurobiology of Disease
Subjects:
Heat shock proteins
Heat shock protein 27
HSPB1
Neuroprotection
Motor neuron
Amyotrophic lateral sclerosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996107002690

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http://www.sciencedirect.com/science/article/pii/S0969996107002690

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