Id Proteins Promote a Cancer Stem Cell Phenotype in Mouse Models of Triple Negative Breast Cancer via Negative Regulation of Robo1

Id Proteins Promote a Cancer Stem Cell Phenotype in Mouse Models of Triple Negative Breast Cancer via Negative Regulation of Robo1

Breast cancers display phenotypic and functional heterogeneity and several lines of evidence support the existence of cancer stem cells (CSCs) in certain breast cancers, a minor population of cells capable of tumor initiation and metastatic dissemination. Identifying factors that regulate the CSC ph...

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Bibliographic Details
Main Authors: Wee S. Teo, Holly Holliday, Nitheesh Karthikeyan, Aurélie S. Cazet, Daniel L. Roden, Kate Harvey, Christina Valbirk Konrad, Reshma Murali, Binitha Anu Varghese, Archana P. Thankamony, Chia-Ling Chan, Andrea McFarland, Simon Junankar, Sunny Ye, Jessica Yang, Iva Nikolic, Jaynish S. Shah, Laura A. Baker, Ewan K. A. Millar, Matthew J. Naylor, Christopher J. Ormandy, Sunil R. Lakhani, Warren Kaplan, Albert S. Mellick, Sandra A. O'Toole, Alexander Swarbrick, Radhika Nair
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Id proteins
Robo1
cancer stem cell
metastasis
Myc signature
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00552/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2020.00552/full

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