Renal Delivery of Pharmacologic Agents During Machine Perfusion to Prevent Ischaemia-Reperfusion Injury: From Murine Model to Clinical Trials

Renal Delivery of Pharmacologic Agents During Machine Perfusion to Prevent Ischaemia-Reperfusion Injury: From Murine Model to Clinical Trials

Donor organ shortage still remains a serious obstacle for the access of wait-list patients to kidney transplantation, the best treatment for End-Stage Kidney Disease (ESKD). To expand the number of transplants, the use of lower quality organs from older ECD or DCD donors has become an established ro...

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Bibliographic Details
Main Authors: Rossana Franzin, Alessandra Stasi, Marco Fiorentino, Simona Simone, Rainer Oberbauer, Giuseppe Castellano, Loreto Gesualdo
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Immunology
Subjects:
renal ischemia/reperfusion
machine perfusion
hypothermic perfusion
normothermic perfusion
DCD − donation after cardiac death
ECD − expanded donor criteria
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.673562/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.673562/full

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