Identification of dual histone modification-binding protein interaction by combining mass spectrometry and isothermal titration calorimetric analysis

Histone posttranslational modifications (HPTMs) play important roles in eukaryotic transcriptional regulation. Recently, it has been suggested that combinatorial modification codes that comprise two or more HPTMs can recruit readers of HPTMs, performing complex regulation of gene expression. However...

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Bibliographic Details
Main Authors: Pu Chen, Zhenchang Guo, Cong Chen, Shanshan Tian, Xue Bai, Guijin Zhai, Zhenyi Ma, Huiyuan Wu, Kai Zhang
Format: Article
Language:English
Published: Elsevier 2020-03-01
Series:Journal of Advanced Research
Online Access:http://www.sciencedirect.com/science/article/pii/S209012321930181X