The β-hairpin of 40S exit channel protein Rps5/uS7 promotes efficient and accurate translation initiation in vivo

The β-hairpin of 40S exit channel protein Rps5/uS7 promotes efficient and accurate translation initiation in vivo

The eukaryotic 43S pre-initiation complex bearing tRNAiMet scans the mRNA leader for an AUG start codon in favorable context. Structural analyses revealed that the β-hairpin of 40S protein Rps5/uS7 protrudes into the 40S mRNA exit-channel, contacting the eIF2∙GTP∙Met-tRNAi ternary complex (TC) and m...

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Bibliographic Details
Main Authors: Jyothsna Visweswaraiah, Yvette Pittman, Thomas E Dever, Alan G Hinnebusch
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-07-01
Series:eLife
Subjects:
translation
initiation
regulation
Rps5/uS7
ribosome
yeast
Online Access:https://elifesciences.org/articles/07939

Internet

https://elifesciences.org/articles/07939

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