Nonsense-mediated decay mechanism is a possible modifying factor of clinical outcome in nonsense cd39 beta thalassemia genotype

Nonsense-mediated decay mechanism is a possible modifying factor of clinical outcome in nonsense cd39 beta thalassemia genotype

<p>Nonsense-mediated mRNA decay (NMD) is a surveillance system to prevent the synthesis of non-functional proteins. In &beta;-thalassemia, NMD may have a role in clinical outcome. An example of premature translation stop codons appearing for the first time is the &beta;-globin cd39 mut...

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Bibliographic Details
Main Authors: Maria Concetta Renda, Angela Vitrano, Massimo Attanasio, Emanuela Fecarotta, Angela Piazza, Antonino Giambona, Germana Fiorentino, Disma Renda, Paolo Rigano, Giuseppina Calvaruso, Filippo Cassarà, Aurelio Maggio
Format: Article
Language:English
Published: PAGEPress Publications 2012-11-01
Series:Thalassemia Reports
Subjects:
nonsense-mediated mRNA decay, beta-thalassemia, clinical outcame, beta-globin gene mutations.
Online Access:http://www.pagepressjournals.org/index.php/thal/article/view/497

Internet

http://www.pagepressjournals.org/index.php/thal/article/view/497

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