Calpain inhibitor MDL28170 improves the transplantation-mediated therapeutic effect of bone marrow-derived mesenchymal stem cells following traumatic brain injury

Calpain inhibitor MDL28170 improves the transplantation-mediated therapeutic effect of bone marrow-derived mesenchymal stem cells following traumatic brain injury

Abstract Background Studies have shown that transplantation of bone marrow-derived mesenchymal stem cells (BMSCs) protects against brain damage. However, the low survival number of transplanted BMSCs remains a pertinent challenge and can be attributed to the unfavorable microenvironment of the injur...

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Bibliographic Details
Main Authors: Jiangnan Hu, Lefu Chen, Xujun Huang, Ke Wu, Saidan Ding, Weikan Wang, Brian Wang, Charity Smith, Changhong Ren, Haoqi Ni, Qichuan ZhuGe, Jianjing Yang
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Stem Cell Research & Therapy
Subjects:
Traumatic brain injury
Bone marrow-derived mesenchymal stem cells
Preconditioning
Calpain inhibitor
MDL28170
Transplantation
Online Access:http://link.springer.com/article/10.1186/s13287-019-1210-4

Internet

http://link.springer.com/article/10.1186/s13287-019-1210-4

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