Increased myocellular lipid and IGFBP‐3 expression in a pre‐clinical model of pancreatic cancer‐related skeletal muscle wasting

Increased myocellular lipid and IGFBP‐3 expression in a pre‐clinical model of pancreatic cancer‐related skeletal muscle wasting

Abstract Background Skeletal muscle wasting (SMW) in cancer patients is associated with increased morbidity, mortality, treatment intolerance and discontinuation, and poor quality of life. This is particularly true for patients with pancreatic ductal adenocarcinoma (PDAC), as over 85% experience SMW...

Full description

Bibliographic Details
Main Authors: Calvin L. Cole, John F. Bachman, Jian Ye, Joseph Murphy, Scott A. Gerber, Christopher A. Beck, Brendan F. Boyce, Gowrishankar Muthukrishnan, Joe V. Chakkalakal, Edward M. Schwarz, David Linehan
Format: Article
Language:English
Published: Wiley 2021-06-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
Myocellular lipid
Murine model
Pancreatic cancer
Skeletal muscle wasting
Online Access:https://doi.org/10.1002/jcsm.12699

Internet

https://doi.org/10.1002/jcsm.12699

Similar Items