Lineage-Specific Genes Are Prominent DNA Damage Hotspots during Leukemic Transformation of B Cell Precursors

Lineage-Specific Genes Are Prominent DNA Damage Hotspots during Leukemic Transformation of B Cell Precursors

In human leukemia, lineage-specific genes represent predominant targets of deletion, with lymphoid-specific genes frequently affected in lymphoid leukemia and myeloid-specific genes in myeloid leukemia. To investigate the basis of lineage-specific alterations, we analyzed global DNA damage in primar...

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Bibliographic Details
Main Authors: Bryant Boulianne, Mark E. Robinson, Philippa C. May, Leandro Castellano, Kevin Blighe, Jennifer Thomas, Alistair Reid, Markus Müschen, Jane F. Apperley, Justin Stebbing, Niklas Feldhahn
Format: Article
Language:English
Published: Elsevier 2017-02-01
Series:Cell Reports
Subjects:
leukemia
B-cell precursors
transformation
oncogenic stress
DNA damage
genomic instability
clonal evolution
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Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717301146

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http://www.sciencedirect.com/science/article/pii/S2211124717301146

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