MiR-135a Protects Vascular Endothelial Cells Against Ventilator-Induced Lung Injury by Inhibiting PHLPP2 to Activate PI3K/Akt Pathway

MiR-135a Protects Vascular Endothelial Cells Against Ventilator-Induced Lung Injury by Inhibiting PHLPP2 to Activate PI3K/Akt Pathway

Background/Aims: Loss of endothelial barrier function plays an important role in the development of ventilator-induced lung injury (VILI). This study aimed to investigate the effects of miR135a on VILI in a model of mechanical stretch (MS)-induced human umbilical vein endothelial cell (HUVEC) injury...

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Bibliographic Details
Main Authors: Xiaodi Yan, Wenqian Li, Liye Yang, Wenwen Dong, Wei Chen, Yanfei Mao, Pingbo Xu, Dongjie Li, Hongbin Yuan, Yong-Hua Li
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-07-01
Series:Cellular Physiology and Biochemistry
Subjects:
Mir-135a
Ventilator-induced lung injury
Human umbilical vein endothelial cells
PI3K
PHLPP
Online Access:https://www.karger.com/Article/FullText/492010

Internet

https://www.karger.com/Article/FullText/492010

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