Nrf2 activation through the PI3K/GSK-3 axis protects neuronal cells from Aβ-mediated oxidative and metabolic damage

Nrf2 activation through the PI3K/GSK-3 axis protects neuronal cells from Aβ-mediated oxidative and metabolic damage

Abstract Background Mounting evidence points to a crucial role of amyloid-β (Aβ) in the pathophysiology of Alzheimer’s disease (AD), a disorder in which brain glucose hypometabolism, downregulation of central elements of phosphorylation pathways, reduced ATP levels, and enhanced oxidative damage coe...

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Bibliographic Details
Main Authors: Krystal Sotolongo, Jorge Ghiso, Agueda Rostagno
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease
Amyloid-β
Mitochondria
Methazolamide
Melatonin
Trolox
Online Access:https://doi.org/10.1186/s13195-019-0578-9

Internet

https://doi.org/10.1186/s13195-019-0578-9

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