Aberrantly Expressed RECQL4 Helicase Supports Proliferation and Drug Resistance of Human Glioma Cells and Glioma Stem Cells

Aberrantly Expressed RECQL4 Helicase Supports Proliferation and Drug Resistance of Human Glioma Cells and Glioma Stem Cells

Anti-tumour therapies eliminate proliferating tumour cells by induction of DNA damage, but genomic aberrations or transcriptional deregulation may limit responses to therapy. Glioblastoma (GBM) is a malignant brain tumour, which recurs inevitably due to chemo- and radio-resistance. Human RecQ helica...

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Bibliographic Details
Main Authors: Sylwia K. Król, Agnieszka Kaczmarczyk, Kamil Wojnicki, Bartosz Wojtas, Bartłomiej Gielniewski, Wieslawa Grajkowska, Katarzyna Kotulska, Cezary Szczylik, Ryszard Czepko, Mariusz Banach, Wojciech Kaspera, Wojciech Szopa, Andrzej Marchel, Tomasz Czernicki, Bozena Kaminska
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Cancers
Subjects:
RecQ helicases
gliomas
gene knockdown
proliferation
drug sensitivity
Online Access:https://www.mdpi.com/2072-6694/12/10/2919

Internet

https://www.mdpi.com/2072-6694/12/10/2919

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