Conventional Anti-glioblastoma Chemotherapy Affects Proteoglycan Composition of Brain Extracellular Matrix in Rat Experimental Model in vivo

Conventional Anti-glioblastoma Chemotherapy Affects Proteoglycan Composition of Brain Extracellular Matrix in Rat Experimental Model in vivo

Temozolomide (TMZ) is a conventional chemotherapy drug for adjuvant treatment of glioblastoma multiforme (GBM), often accompanied by dexamethasone (DXM) to prevent brain oedema and alleviate clinical side effects. Here, we aimed to investigate an ability of the drugs to affect normal brain tissue in...

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Bibliographic Details
Main Authors: Alexandra Y. Tsidulko, Cynthia Bezier, Gabin de La Bourdonnaye, Anastasia V. Suhovskih, Tatiana M. Pankova, Galina M. Kazanskaya, Svetlana V. Aidagulova, Elvira V. Grigorieva
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Pharmacology
Subjects:
glioblastoma multiforme
temozolomide
dexamethasone
extracellular matrix
proteoglycan
glycosaminoglycan
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01104/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.01104/full

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