Dynamic Profiling of Insulin Secretion and ATP Generation in Isolated Human and Mouse Islets Reveals Differential Glucose Sensitivity

Dynamic Profiling of Insulin Secretion and ATP Generation in Isolated Human and Mouse Islets Reveals Differential Glucose Sensitivity

Background/Aims: Rodent islets are often used for basic science research but they do not always recapitulate signalling events in human islets. This study evaluated the glucose-dependent responses of human and mouse islets in terms of dynamic insulin secretion, metabolic coupling and the role of glu...

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Bibliographic Details
Main Authors: Attilio Pingitore, Inmaculada Ruz-Maldonado, Bo Liu, Guo Cai Huang, Pratik Choudhary, Shanta J. Persaud
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2017-11-01
Series:Cellular Physiology and Biochemistry
Subjects:
Islets of Langerhans
Insulin secretion
ATP generation
Glucose transporters
Metabolic coupling
GLUT1
Online Access:https://www.karger.com/Article/FullText/485532

Internet

https://www.karger.com/Article/FullText/485532

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