Structural and Mechanistic Analyses Reveal a Unique Cas4-like Protein in the Mimivirus Virophage Resistance Element System

Summary: A clustered regularly interspaced short palindromic repeats (CRISPR)-like “mimivirus virophage resistance element” (MIMIVIRE) system, which contains specific cascade genes and a CRISPR array against virophages, was reported in mimiviruses. An essential component of the MIMIVIRE system is R3...

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Bibliographic Details
Main Authors: Chao Dou, Mingjing Yu, Yijun Gu, Jinjing Wang, Kun Yin, Chunlai Nie, Xiaofeng Zhu, Shiqian Qi, Yuquan Wei, Wei Cheng
Format: Article
Language:English
Published: Elsevier 2018-05-01
Series:iScience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004218300336