LINE-1 hypomethylation is not a common event in preneoplastic stages of gastric carcinogenesis

Abstract LINE-1 hypomethylation is widely accepted as marker for global genomic DNA hypomethylation, which is a frequent event in cancer. The aim of the study was to evaluate LINE-1 methylation status at different stages of gastric carcinogenesis and evaluate its prognostic potential in clinical set...

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Bibliographic Details
Main Authors: Juozas Kupcinskas, Ruta Steponaitiene, Cosima Langner, Giedre Smailyte, Jurgita Skieceviciene, Limas Kupcinskas, Peter Malfertheiner, Alexander Link
Format: Article
Language:English
Published: Nature Publishing Group 2017-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-05143-0