Evolutionarily Selected Overexpression of the Cytokine BAFF Enhances Mucosal Immune Response Against P. falciparum

Evolutionarily Selected Overexpression of the Cytokine BAFF Enhances Mucosal Immune Response Against P. falciparum

We have previously shown that a variant of the TNFSF13B gene that we called BAFF-var increases the production of the cytokine BAFF, upregulating humoral immunity and increasing the risk for certain autoimmune diseases. In addition, genetic population signatures revealed that BAFF-var was evolutionar...

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Bibliographic Details
Main Authors: Valeria Lodde, Matteo Floris, Isabel Beerman, Rachel Munk, Rajan Guha, Maristella Steri, Valeria Orrù, Kotb Abdelmohsen, Peter D. Crompton, Myriam Gorospe, Maria Laura Idda, Francesco Cucca
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Immunology
Subjects:
malaria
BAFF
gene regulation
evolution
immune regulation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.575103/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.575103/full

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