Detection and Investigation of Eagle Effect Resistance to Vancomycin in Clostridium difficile With an ATP-Bioluminescence Assay

Detection and Investigation of Eagle Effect Resistance to Vancomycin in Clostridium difficile With an ATP-Bioluminescence Assay

Vancomycin was bactericidal against Clostridium difficile at eightfold the minimum inhibitory concentration (MIC) using a traditional minimum bactericidal concentration (MBC) assay. However, at higher concentrations up to 64 × MIC, vancomycin displayed a paradoxical “more-drug-kills-less” Eagle effe...

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Bibliographic Details
Main Authors: Angie M. Jarrad, Mark A. T. Blaskovich, Anggia Prasetyoputri, Tomislav Karoli, Karl A. Hansford, Matthew A. Cooper
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Microbiology
Subjects:
Clostridium difficile
Eagle effect
vancomycin
antibiotic resistance
ATP-bioluminescence
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.01420/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2018.01420/full

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