CRISPR/Cas9 Immunoengineering of Hoxb8-Immortalized Progenitor Cells for Revealing CCR7-Mediated Dendritic Cell Signaling and Migration Mechanisms in vivo

CRISPR/Cas9 Immunoengineering of Hoxb8-Immortalized Progenitor Cells for Revealing CCR7-Mediated Dendritic Cell Signaling and Migration Mechanisms in vivo

To present antigens to cognate T cells, dendritic cells (DCs) exploit the chemokine receptor CCR7 to travel from peripheral tissue via afferent lymphatic vessels to directly enter draining lymph nodes through the floor of the subcapsular sinus. Here, we combined unlimited proliferative capacity of c...

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Bibliographic Details
Main Authors: Swantje I. Hammerschmidt, Kathrin Werth, Michael Rothe, Melanie Galla, Marc Permanyer, Gwendolyn E. Patzer, Anja Bubke, David N. Frenk, Anton Selich, Lucas Lange, Axel Schambach, Berislav Bošnjak, Reinhold Förster
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Immunology
Subjects:
CRISPR/Cas9
Hoxb8
immortalization
dendritic cells
migration
CCR7
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01949/full

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https://www.frontiersin.org/article/10.3389/fimmu.2018.01949/full

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