Metalloprotease Adam10 suppresses epilepsy through repression of hippocampal neuroinflammation

Metalloprotease Adam10 suppresses epilepsy through repression of hippocampal neuroinflammation

Abstract Background Mice with pilocarpine-induced temporal lobe epilepsy (TLE) are characterized by intense hippocampal neuroinflammation, a prominent pathological hallmark of TLE that is known to contribute to neuronal hyperexcitability. Recent studies indicate that Adam10, a member of a disintegri...

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Bibliographic Details
Main Authors: Xinjian Zhu, Xiaolin Li, Mengyi Zhu, Kangni Xu, Li Yang, Bing Han, Rongrong Huang, Aifeng Zhang, Honghong Yao
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Journal of Neuroinflammation
Subjects:
Metalloprotease
Adam10
Hippocampus
Neuroinflammation
Temporal lobe epilepsy
Online Access:http://link.springer.com/article/10.1186/s12974-018-1260-z

Internet

http://link.springer.com/article/10.1186/s12974-018-1260-z

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