Measuring NQO1 Bioactivation Using [<sup>2</sup>H<sub>7</sub>]Glucose

Treatment of cancers with β-lapachone causes NAD(P)H: quinone oxidoreductase 1 (NQO1) to generate an unstable hydroquinone that regenerates itself in a futile cycle while producing reactive oxygen species (ROS) in the form of superoxide and subsequently hydrogen peroxide. Rapid accumulation of ROS d...

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Bibliographic Details
Main Authors: Rohit Mahar, Mario C. Chang, Matthew E. Merritt
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cancers
Subjects:
HDO
Online Access:https://www.mdpi.com/2072-6694/13/16/4165