Fyn kinase inhibition reduces protein aggregation, increases synapse density and improves memory in transgenic and traumatic Tauopathy

Fyn kinase inhibition reduces protein aggregation, increases synapse density and improves memory in transgenic and traumatic Tauopathy

Abstract Accumulation of misfolded phosphorylated Tau (Tauopathy) can be triggered by mutations or by trauma, and is associated with synapse loss, gliosis, neurodegeneration and memory deficits. Fyn kinase physically associates with Tau and regulates subcellular distribution. Here, we assessed wheth...

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Bibliographic Details
Main Authors: Si Jie Tang, Arman Fesharaki-Zadeh, Hideyuki Takahashi, Sarah Helena Nies, Levi M. Smith, Anin Luo, Annabel Chyung, Marius Chiasseu, Stephen M. Strittmatter
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Acta Neuropathologica Communications
Subjects:
Tau
Fyn
Tauopathy
Alzheimer’s disease
Traumatic brain injury
Stress
Online Access:http://link.springer.com/article/10.1186/s40478-020-00976-9

Internet

http://link.springer.com/article/10.1186/s40478-020-00976-9

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