Variation in RAD51 details a hub of functions: opportunities to advance cancer diagnosis and therapy [version 2; referees: 4 approved]

Loss of genome stability is one of the hallmarks of the enabling characteristics of cancer development. Homologous recombination is a DNA repair process that often breaks down as a prelude to developing cancer. Conversely, homologous recombination can be the Achilles’ heel in common anti-cancer ther...

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Bibliographic Details
Main Authors: Nick LL van der Zon, Roland Kanaar, Claire Wyman
Format: Article
Language:English
Published: F1000 Research Ltd 2018-12-01
Series:F1000Research
Online Access:https://f1000research.com/articles/7-1453/v2