Huzhangoside A Suppresses Tumor Growth through Inhibition of Pyruvate Dehydrogenase Kinase Activity

Huzhangoside A Suppresses Tumor Growth through Inhibition of Pyruvate Dehydrogenase Kinase Activity

Aerobic glycolysis is one of the important metabolic characteristics of many malignant tumors. Pyruvate dehydrogenase kinase (PDHK) plays a key role in aerobic glycolysis by phosphorylating the E1α subunit of pyruvate dehydrogenase (PDH). Hence, PDHK has been recognized as a molecular targe...

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Bibliographic Details
Main Authors: Choong-Hwan Kwak, Jung-Hee Lee, Eun-Yeong Kim, Chang Woo Han, Keuk-Jun Kim, Hanna Lee, MyoungLae Cho, Se Bok Jang, Cheorl-Ho Kim, Tae-Wook Chung, Ki-Tae Ha
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Cancers
Subjects:
Huzhangoside A
Warburg effect
Pyruvate dehydrogenase kinase
Glycolysis
Apoptosis
Online Access:https://www.mdpi.com/2072-6694/11/5/712

Internet

https://www.mdpi.com/2072-6694/11/5/712

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