The aryl hydrocarbon receptor controls cyclin O to promote epithelial multiciliogenesis

The aryl hydrocarbon receptor controls cyclin O to promote epithelial multiciliogenesis

Epithelia are barriers against environmental insults and express the transcription factor aryl hydrocarbon receptor (AhR). Here the authors show that AhR regulates multiciliogenesis via cyclin O and Multicilin in a Notch-dependent manner and that this is blocked by toxic ligands.

Bibliographic Details
Main Authors: Matteo Villa, Stefania Crotta, Kevin S. Dingwell, Elizabeth M. A. Hirst, Manolis Gialitakis, Helena Ahlfors, James C. Smith, Brigitta Stockinger, Andreas Wack
Format: Article
Language:English
Published: Nature Publishing Group 2016-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms12652

Internet

https://doi.org/10.1038/ncomms12652

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