The aryl hydrocarbon receptor controls cyclin O to promote epithelial multiciliogenesis

Epithelia are barriers against environmental insults and express the transcription factor aryl hydrocarbon receptor (AhR). Here the authors show that AhR regulates multiciliogenesis via cyclin O and Multicilin in a Notch-dependent manner and that this is blocked by toxic ligands.

Bibliographic Details
Main Authors:	Matteo Villa, Stefania Crotta, Kevin S. Dingwell, Elizabeth M. A. Hirst, Manolis Gialitakis, Helena Ahlfors, James C. Smith, Brigitta Stockinger, Andreas Wack
Format:	Article
Language:	English
Published:	Nature Publishing Group 2016-08-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms12652

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spelling	doaj-2586c152044d48ffa6ee83a3bf1f6f6c2021-05-11T10:56:14ZengNature Publishing GroupNature Communications2041-17232016-08-017111110.1038/ncomms12652The aryl hydrocarbon receptor controls cyclin O to promote epithelial multiciliogenesisMatteo Villa0Stefania Crotta1Kevin S. Dingwell2Elizabeth M. A. Hirst3Manolis Gialitakis4Helena Ahlfors5James C. Smith6Brigitta Stockinger7Andreas Wack8Laboratory of AhRimmunity, The Francis Crick Institute, Mill Hill LaboratoryLaboratory of Immunoregulation, The Francis Crick Institute, Mill Hill LaboratoryLaboratory of Developmental Biology, The Francis Crick Institute, Mill Hill LaboratoryEM Technology Platform, The Francis Crick Institute, Mill Hill LaboratoryLaboratory of AhRimmunity, The Francis Crick Institute, Mill Hill LaboratoryLymphocyte Signalling and Development, The Babraham InstituteLaboratory of Developmental Biology, The Francis Crick Institute, Mill Hill LaboratoryLaboratory of AhRimmunity, The Francis Crick Institute, Mill Hill LaboratoryLaboratory of Immunoregulation, The Francis Crick Institute, Mill Hill LaboratoryEpithelia are barriers against environmental insults and express the transcription factor aryl hydrocarbon receptor (AhR). Here the authors show that AhR regulates multiciliogenesis via cyclin O and Multicilin in a Notch-dependent manner and that this is blocked by toxic ligands.https://doi.org/10.1038/ncomms12652
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Matteo Villa Stefania Crotta Kevin S. Dingwell Elizabeth M. A. Hirst Manolis Gialitakis Helena Ahlfors James C. Smith Brigitta Stockinger Andreas Wack
spellingShingle	Matteo Villa Stefania Crotta Kevin S. Dingwell Elizabeth M. A. Hirst Manolis Gialitakis Helena Ahlfors James C. Smith Brigitta Stockinger Andreas Wack The aryl hydrocarbon receptor controls cyclin O to promote epithelial multiciliogenesis Nature Communications
author_facet	Matteo Villa Stefania Crotta Kevin S. Dingwell Elizabeth M. A. Hirst Manolis Gialitakis Helena Ahlfors James C. Smith Brigitta Stockinger Andreas Wack
author_sort	Matteo Villa
title	The aryl hydrocarbon receptor controls cyclin O to promote epithelial multiciliogenesis
title_short	The aryl hydrocarbon receptor controls cyclin O to promote epithelial multiciliogenesis
title_full	The aryl hydrocarbon receptor controls cyclin O to promote epithelial multiciliogenesis
title_fullStr	The aryl hydrocarbon receptor controls cyclin O to promote epithelial multiciliogenesis
title_full_unstemmed	The aryl hydrocarbon receptor controls cyclin O to promote epithelial multiciliogenesis
title_sort	aryl hydrocarbon receptor controls cyclin o to promote epithelial multiciliogenesis
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2016-08-01
description	Epithelia are barriers against environmental insults and express the transcription factor aryl hydrocarbon receptor (AhR). Here the authors show that AhR regulates multiciliogenesis via cyclin O and Multicilin in a Notch-dependent manner and that this is blocked by toxic ligands.
url	https://doi.org/10.1038/ncomms12652
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The aryl hydrocarbon receptor controls cyclin O to promote epithelial multiciliogenesis

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