Epithelial Cell-Derived a Disintegrin and Metalloproteinase-17 Confers Resistance to Colonic Inflammation Through EGFR Activation

Epithelial Cell-Derived a Disintegrin and Metalloproteinase-17 Confers Resistance to Colonic Inflammation Through EGFR Activation

Epithelial regeneration is a key process for the recovery from ulcerative colitis (UC). Here we demonstrate that a disintegrin and metalloproteinase-17 (ADAM17), a main sheddase for tumor necrosis factor (TNF)-α, is essential for defensive epithelial properties against UC by promoting epithelial cel...

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Bibliographic Details
Main Authors: Masayuki Shimoda, Keisuke Horiuchi, Aya Sasaki, Tetsuya Tsukamoto, Koji Okabayashi, Hirotoshi Hasegawa, Yuko Kitagawa, Yasunori Okada
Format: Article
Language:English
Published: Elsevier 2016-03-01
Series:EBioMedicine
Subjects:
A disintegrin and metalloproteinase 17 (ADAM17)
Ulcerative colitis
Epidermal growth factor receptor (EGFR)
Goblet cell
Epithelial barrier
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396416300408

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http://www.sciencedirect.com/science/article/pii/S2352396416300408

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