PRAS40 plays a pivotal role in protecting against stroke by linking the Akt and mTOR pathways

PRAS40 plays a pivotal role in protecting against stroke by linking the Akt and mTOR pathways

The proline-rich Akt substrate of 40 kDa (PRAS40) protein is not only a substrate of the protein kinase Akt but also a component of the mTOR complex 1 (mTORC1), thus it links the Akt and the mTOR pathways. We investigated the potential protective role of PRAS40 in cerebral ischemia and its underlyin...

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Bibliographic Details
Main Authors: Xiaoxing Xiong, Rong Xie, Hongfei Zhang, Lijuan Gu, Weiying Xie, Michelle Cheng, Zhihong Jian, Kristina Kovacina, Heng Zhao
Format: Article
Language:English
Published: Elsevier 2014-06-01
Series:Neurobiology of Disease
Subjects:
Focal cerebral ischemia
Akt
Stroke
mTOR
PRAS40
PTEN
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114000485

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http://www.sciencedirect.com/science/article/pii/S0969996114000485

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