The Presence of a CMV Immunodominant Allele in the Recipient Is Associated With Increased Survival in CMV Positive Patients Undergoing Haploidentical Hematopoietic Stem Cell Transplantation

The Presence of a CMV Immunodominant Allele in the Recipient Is Associated With Increased Survival in CMV Positive Patients Undergoing Haploidentical Hematopoietic Stem Cell Transplantation

Specific major histocompatibility (MHC) class I alleles dominate anti-CMV responses in a hierarchal manner. These CMV immunodominant (IMD) alleles are associated with a higher magnitude and frequency of cytotoxic lymphocyte responses as compared to other human leukocyte antigen (HLA) alleles. CMV re...

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Bibliographic Details
Main Authors: Dolores Grosso, Benjamin Leiby, Matthew Carabasi, Joanne Filicko-O'Hara, Sameh Gaballa, William O'Hara, John L. Wagner, Neal Flomenberg
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Oncology
Subjects:
CMV
immunodominant allele
haploidentical
transplant outcomes
graft versus host disease
DNA terminase complex inhibitor
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00888/full

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https://www.frontiersin.org/article/10.3389/fonc.2019.00888/full

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