Derivatives of 3-Aminopyrazine-2-carboxamides: Synthesis, Antimicrobial Evaluation, and in Vitro Cytotoxicity

Derivatives of 3-Aminopyrazine-2-carboxamides: Synthesis, Antimicrobial Evaluation, and in Vitro Cytotoxicity

We report the design, synthesis, and in vitro antimicrobial activity of a series of <i>N</i>-substituted 3-aminopyrazine-2-carboxamides with free amino groups in position 3 on the pyrazine ring. Based on various substituents on the carboxamidic moiety, the series is subdivided into benzy...

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Bibliographic Details
Main Authors: Ghada Bouz, Lucia Semelková, Ondřej Janďourek, Klára Konečná, Pavla Paterová, Lucie Navrátilová, Vladimír Kubíček, Jiří Kuneš, Martin Doležal, Jan Zitko
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Molecules
Subjects:
aminopyrazine
antibacterial activity
antifungal activity
antimycobacterial activity
cytotoxicity
pyrazinamide derivatives
Online Access:https://www.mdpi.com/1420-3049/24/7/1212

Internet

https://www.mdpi.com/1420-3049/24/7/1212

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