Urine-sample-derived human induced pluripotent stem cells as a model to study PCSK9-mediated autosomal dominant hypercholesterolemia

Urine-sample-derived human induced pluripotent stem cells as a model to study PCSK9-mediated autosomal dominant hypercholesterolemia

Proprotein convertase subtilisin kexin type 9 (PCSK9) is a critical modulator of cholesterol homeostasis. Whereas PCSK9 gain-of-function (GOF) mutations are associated with autosomal dominant hypercholesterolemia (ADH) and premature atherosclerosis, PCSK9 loss-of-function (LOF) mutations have a card...

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Bibliographic Details
Main Authors: Karim Si-Tayeb, Salam Idriss, Benoite Champon, Amandine Caillaud, Matthieu Pichelin, Lucie Arnaud, Patricia Lemarchand, Cédric Le May, Kazem Zibara, Bertrand Cariou
Format: Article
Language:English
Published: The Company of Biologists 2016-01-01
Series:Disease Models & Mechanisms
Subjects:
Urine-derived somatic cells
Human induced pluripotent stem cells
Hepatocyte differentiation
Autosomal dominant hypercholesterolemia
PCSK9
Online Access:http://dmm.biologists.org/content/9/1/81

Internet

http://dmm.biologists.org/content/9/1/81

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