Predisposition to Childhood Otitis Media and Genetic Polymorphisms within the Toll-Like Receptor 4 (TLR4) Locus.

Predisposition to Childhood Otitis Media and Genetic Polymorphisms within the Toll-Like Receptor 4 (TLR4) Locus.

Predisposition to childhood otitis media (OM) has a strong genetic component, with polymorphisms in innate immunity genes suspected to contribute to risk. Studies on several genes have been conducted, but most associations have failed to replicate in independent cohorts.We investigated 53 gene polym...

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Bibliographic Details
Main Authors: Lena Hafrén, Elisabet Einarsdottir, Erna Kentala, Sari Hammarén-Malmi, Mahmood F Bhutta, Carol J MacArthur, Beth Wilmot, Margaretha Casselbrant, Yvette P Conley, Daniel E Weeks, Ellen M Mandel, Outi Vaarala, Anna Kallio, Merit Melin, Janne K Nieminen, Eira Leinonen, Juha Kere, Petri S Mattila
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4503307?pdf=render

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http://europepmc.org/articles/PMC4503307?pdf=render

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