Oxidative Stress-Induced Sirtuin1 Downregulation Correlates to HIF-1α, GLUT-1, and VEGF-A Upregulation in Th1 Autoimmune Hashimoto’s Thyroiditis

Oxidative Stress-Induced Sirtuin1 Downregulation Correlates to HIF-1α, GLUT-1, and VEGF-A Upregulation in Th1 Autoimmune Hashimoto’s Thyroiditis

In Hashimoto’s thyroiditis (HT), oxidative stress (OS) is driven by Th1 cytokines’ response interfering with the normal function of thyrocytes. OS results from an imbalance between an excessive production of reactive oxygen species (ROS) and a lowering of antioxidant production. Moreover, OS has bee...

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Bibliographic Details
Main Authors: Michaël Hepp, Alexis Werion, Axel De Greef, Christine de Ville de Goyet, Marc de Bournonville, Catherine Behets, Benoit Lengelé, Chantal Daumerie, Michel Mourad, Marian Ludgate, Marie-Christine Many, Virginie Joris, Julie Craps
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
Hashimoto’s thyroiditis
oxidative stress
NOX4
Sirtuin1
HIF-1α
Online Access:https://www.mdpi.com/1422-0067/22/8/3806

Internet

https://www.mdpi.com/1422-0067/22/8/3806

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