The AMPK-PGC-1α signaling axis regulates the astrocyte glutathione system to protect against oxidative and metabolic injury

The AMPK-PGC-1α signaling axis regulates the astrocyte glutathione system to protect against oxidative and metabolic injury

Neurons are highly sensitive to metabolic and oxidative injury, but endogenous astrocyte mechanisms have a critical capacity to provide protection from these stresses. We previously reported that the master regulator PGC-1α (peroxisome proliferator-activated receptor gamma coactivator-1α) is necessa...

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Bibliographic Details
Main Authors: Xiaoxin Guo, Qi Jiang, Alessandra Tuccitto, Darren Chan, Samih Alqawlaq, Gah-Jone Won, Jeremy M. Sivak
Format: Article
Language:English
Published: Elsevier 2018-05-01
Series:Neurobiology of Disease
Subjects:
Astrocyte
PGC-1α
AMPK
Glutathione
Retina
ROS
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996118300366

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http://www.sciencedirect.com/science/article/pii/S0969996118300366

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