The AMPK-PGC-1α signaling axis regulates the astrocyte glutathione system to protect against oxidative and metabolic injury
Neurons are highly sensitive to metabolic and oxidative injury, but endogenous astrocyte mechanisms have a critical capacity to provide protection from these stresses. We previously reported that the master regulator PGC-1α (peroxisome proliferator-activated receptor gamma coactivator-1α) is necessa...
Main Authors: | Xiaoxin Guo, Qi Jiang, Alessandra Tuccitto, Darren Chan, Samih Alqawlaq, Gah-Jone Won, Jeremy M. Sivak |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2018-05-01
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Series: | Neurobiology of Disease |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996118300366 |
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