Discovery of a dual inhibitor of NQO1 and GSTP1 for treating glioblastoma

Discovery of a dual inhibitor of NQO1 and GSTP1 for treating glioblastoma

Abstract Background Glioblastoma (GBM) is a universally lethal tumor with frequently overexpressed or mutated epidermal growth factor receptor (EGFR). NADPH quinone oxidoreductase 1 (NQO1) and glutathione-S-transferase Pi 1 (GSTP1) are commonly upregulated in GBM. NQO1 and GSTP1 decrease the formati...

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Bibliographic Details
Main Authors: Kecheng Lei, Xiaoxia Gu, Alvaro G. Alvarado, Yuhong Du, Shilin Luo, Eun Hee Ahn, Seong Su Kang, Bing Ji, Xia Liu, Hui Mao, Haian Fu, Harley I. Kornblum, Lingjing Jin, Hua Li, Keqiang Ye
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Journal of Hematology & Oncology
Subjects:
Oxidative stress
NQO1
GSTP1
GBM
Small molecular inhibitor
Online Access:http://link.springer.com/article/10.1186/s13045-020-00979-y

Internet

http://link.springer.com/article/10.1186/s13045-020-00979-y

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