CHF6001 Inhibits NF-κB Activation and Neutrophilic Recruitment in LPS-Induced Lung Inflammation in Mice

CHF6001 Inhibits NF-κB Activation and Neutrophilic Recruitment in LPS-Induced Lung Inflammation in Mice

Inhibitors of phosphodiesterase 4 (PDE4) are potent anti-inflammatory agents, inhibiting the production of inflammatory mediators through the elevation of intracellular cAMP concentrations. We studied the activity of a novel PDE4 inhibitor, CHF6001, both in vitro in human cells and in vivo, using bi...

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Bibliographic Details
Main Authors: Fabio F. Stellari, Angelo Sala, Francesca Ruscitti, Carola Buccellati, Andrew Allen, Patrizia Risé, Maurizio Civelli, Gino Villetti
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Pharmacology
Subjects:
LPS
inhalation towers
NF-kB
in vivo bioluminescence imaging
lung inflammation
mouse model
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01337/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.01337/full

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