CREB mediates the insulinotropic and anti-apoptotic effects of GLP-1 signaling in adult mouse β-cells

CREB mediates the insulinotropic and anti-apoptotic effects of GLP-1 signaling in adult mouse β-cells

Objective: Glucagon-like peptide-1 (GLP-1) plays a major role in pancreatic β-cell function and survival by increasing cytoplasmic cAMP levels, which are thought to affect transcription through activation of the basic leucine zipper (bZIP) transcription factor CREB. Here, we test CREB function in th...

Full description

Bibliographic Details
Main Authors: Soona Shin, John Le Lay, Logan J. Everett, Rana Gupta, Kiran Rafiq, Klaus H. Kaestner
Format: Article
Language:English
Published: Elsevier 2014-11-01
Series:Molecular Metabolism
Subjects:
CREB
Leucine zipper transcription factor
cAMP signaling
Conditional gene ablation
Apoptosis
p21
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877814001446

Internet

http://www.sciencedirect.com/science/article/pii/S2212877814001446

Similar Items