Thrombomodulin Modulates Dendritic Cells via Both Antagonism of High Mobility Group Protein B1 and an Independent Mechanism

Thrombomodulin Modulates Dendritic Cells via Both Antagonism of High Mobility Group Protein B1 and an Independent Mechanism

Background: Thrombomodulin treatment modulates the properties of dendritic cells (DCs) converting them from immunogenic to tolerogenic and inducing its own expression on DCs. Thrombomodulin binds to the inflammatory mediator, high mobility group protein B1 (HMGB1), antagonizing signalling through it...

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Bibliographic Details
Main Authors: Masaaki Toda, Corina N. D'Alessandro-Gabazza, Takehiro Takagi, Ayshwarya-Lakshmi Chelakkot-Govindalayathila, Osamu Taguchi, Ziaurahman Roeen, Seiichi Munesue, Yasuhiko Yamamoto, Hiroshi Yamamoto, Esteban C. Gabazza, John Morser
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Allergology International
Subjects:
dendritic cells (DCs)
high mobility group protein B1 (HMGB1 protein)
inflammation
innate immunity
receptor for advanced glycation end products (RAGE)
Online Access:http://www.sciencedirect.com/science/article/pii/S1323893015300095

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http://www.sciencedirect.com/science/article/pii/S1323893015300095

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