No evidence for association of MTHFR 677C>T and 1298A>C variants with placental DNA methylation

No evidence for association of MTHFR 677C>T and 1298A>C variants with placental DNA methylation

Abstract Background 5,10-Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in one-carbon metabolism that ensures the availability of methyl groups for methylation reactions. Two single-nucleotide polymorphisms (SNPs) in the MTHFR gene, 677C>T and 1298A>C, result in a thermolabile enz...

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Bibliographic Details
Main Authors: Giulia F. Del Gobbo, E. Magda Price, Courtney W. Hanna, Wendy P. Robinson
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Clinical Epigenetics
Subjects:
MTHFR
DNA methylation
Placenta
One-carbon metabolism
450k array
Neural tube defects
Online Access:http://link.springer.com/article/10.1186/s13148-018-0468-1

Internet

http://link.springer.com/article/10.1186/s13148-018-0468-1

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